Defending his WBC Silver heavyweight title, Whyte was in far better shape than his Australian counterpart and took advantage in winning every round.
Browne was always looking for a one-punch haymaker finish but just couldn’t get close enough to a trim and lively Whyte, who opened up a nasty cut in the very first session.
The eye damage worsened every round before a busted nose added to Browne’s troubles in the fifth.
Whyte turned Browne’s lights out in the sixth with a sickening blow.
‘Big Daddy’ was worryingly down for some time and didn’t move, but with the help of the ringside medics, he was soon back to his feet to the relief of Whyte and the UK crowd.
Whyte could now move on to a rematch with Anthony Joshua should his old rival come through Joseph Parker in Cardiff next week.
On the undercard and coming out of the blocks like a lightning bolt, Callum Johnson ripped away Frank Buglioni’s Lonsdale Belt with a spectacular first-round knockout.
‘The One’ scored with several solid shots early on before Buglioni hit the deck and was unsteady on his feet. Johnson capitalized and piled on the pressure to force the end and claim the UK light-heavyweight strap.
Lewis Ritson must have thought it was Christmas come early as the Newcastle man retained his British lightweight belt for the second time.
In astonishing tactics, challenger Scott Cardle, not a known puncher, threw defense out of the window as he attempted a smash and grab on Ritson’s title.
With more power in his arsenal, there was only ever going to be one winner in a firefight, and sensing his man was in trouble, trainer Joe Gallagher threw in the towel following a standing eight count and a lack of covering up from Cardle.
Where Cardle goes from here is anyone’s guess, as a lack of explosion in his fists would seemingly rule out a move up in weight.
Dereck Chisora and David Haye went face-to-face on Saturday night after ‘Del Boy’ scored a crushing second round knockout over an out-of-shape Zakaria Azzouzi.
The former world title challenger was returning to action following a defeat to European champion Agit Kabayel on the back of being offered a hefty cheque to face Joe Joyce on May 5.
Haye wants his former foe to battle the 2016 Olympic silver medallist on the undercard of his rematch with Tony Bellew, although Chisora is playing hardball as he proved at The O2 Arena.
‘If he beats me, you give me £1,” Chisora offered Haye live on Sky Sports. “But if I win, I want your purse from the Bellew fight and your TV rights!”
Clearly having none of it, Haye basically told Chisora where he could stick his offer by saying: ‘You know the real world doesn’t work like that, and deciding to move on from the fight.
It now seems as though Joyce will turn his attention to landing an encounter with Commonwealth title holder Lenroy Thomas on the back of a disappointing first-round technical draw with Dave Allen.
Even if Joyce picked up the strap against Thomas, Chisora admitted it wouldn’t be enough of an incentive to lure him into accepting the fight.
Following on from Chisora, Anthony Fowler made it five straight wins as a pro by grinding down Kalilou Dembele on the way to what was a slightly controversial stoppage by referee Bob Williams.
Fowler, who had dropped Dembele earlier in the contest, crunched a body shot into his opponent’s midriff in the fifth before Williams waved the fight off as the Frenchman got to his feet.
Dembele argued the timing of the decision to end the bout, although Fowler was well on top, and it seemed just a matter of time before the Liverpool man forced the knockout.
Following his World Boxing Super Series disappointment, super middleweight Jamie Cox is back in the win column courtesy of a second round knockout of Harry Matthews. At the same time, Craig Richards halted Ivan Stupalo in three at light-heavyweight.
Richard Riakporhe moved to 6-0 but not without a scare along the way against Adam Williams. The cruiserweight was dropped in the first round but came back strong in the second and eventually got the job done in the third.
Super bantamweight prospect Louie Lynn began proceedings with a stoppage victory over Michael Horobin on his professional debut.
Before the main event, floater Chris Kongo scored a six-round points triumph.
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