Despite being promoted and managed by McGuigan solely since leaving Matchroom Sport in 2013, Frampton has decided the time is right to branch out on his own.
Outlining the situation on Monday, Frampton said: “I can confirm I have parted company with Barry McGuigan and Cyclone Promotions.
“I would like to thank Barry, the McGuigan family and Cyclone promotions for our time together.
“Having taken time to consider my future and discussed it with those closest to me, I am confident that now is the right time to move forward and take my career into my own hands.”
Potentially edging toward a move to being represented by another UK promoter, Frampton stated he expects his next fight to be in front of his home fans in Belfast.
“I still believe that I’m the best featherweight in the world and I promise my fans that I am continuing with my efforts to get my homecoming fight rescheduled in the very near future.”
Frampton, 30, was due to battle Andres Gutierrez last month until the fight was called off due to a shower accident involving the Mexican.
Just 24 hours prior to fight night, Frampton had failed weight before rumors began of a rift between the McGuigans, including long-time trainer Shane, Barry’s son.
‘The Jackal’ now becomes one of the hottest commodities on the free agent market and has already been linked to the likes of Adam Booth, Jim McDonnell and even some top United States coaches moving forward.