The 26 year-old maintained his high KO ratio by putting Algieri on the canvas three times on the way to an impressive fifth round stoppage victory.
Spence is highly touted as a potential future pound for pound king by many and can now boast a feat neither Manny Pacquiao nor Amir Khan could manage in ending a fight with former world champion Algieri early.
The southpaw is now 20-0 in the paid ranks and has only been taken past five rounds on three occasions.
Prior to the main event, 2012 Olympian Marcus Browne was dropped for the first time in his career as the American struggled to get to grips with Radivoje Kalajdzic.
In a messy affair marred by excessive holding, Browne was rocked on more than one occasion before seeing out 76-74, 76-75 triumph with two of the judges, with a third having it 74-76 for Kalajdzic after eight rounds.
A rematch could be on the cards between the pair, whilst Browne – on this evidence, looks to be short of the necessary skill set to challenge any of the current world light heavyweight champions.