06
Aug
2020

BOXERS TAKE NOTE! – VADA unveils PROHIBITED SUBSTANCE list update

RINGSIDE 08/01/2020

Boxers have to take note of the following update to the Voluntary Anti-Doping Association (VADA) Official Prohibited List (Substances and Methods).

All pro sportspeople have been advised to follow the guidelines to avoid a positive drug test.

VADA guidelines concerning these specific substances and groups are intended to closely track internationally recognized standards for substances prohibited by sport, such as the World Anti-Doping Agency (WADA) Official Prohibited List of 2020.

Therefore, nomenclature for these substances, classification groups and other uses by the WADA Prohibited List will be preserved, unless otherwise specified by VADA.

VADA Prohibited List

PROHIBITED SUBSTANCES

The following classification groups and substances are prohibited at all times during participation in the VADA program. The following classification groups and substances listed herein are not restricted to the specifically-listed common or chemical names, nor are they restricted to the specific compounds or isomers listed below. Moreover, VADA has the right, at any time, to modify, edit, and add any substance or method according to any new laws, guidelines, VADA policies, or anti-doping ideals.

S0. NON-APPROVED SUBSTANCES

Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times.

S1. ANABOLIC AGENTS

Anabolic agents are prohibited.

Anabolic Androgenic Steroids (AAS)
when administered exogenously, including but not limited to:

1-Androstenediol (5a -androst-1-ene-3β,17β-diol);

1-Androstenedione (5a -androst-1-ene-3,17-dione);

1-Androsterone (3a -hydroxy-5a-androst-1-ene-17-one);

1-Epiandrosterone (3β-hydroxy-5a-androst-1-ene-17-one);

1-Testosterone (17β-hydroxy-5a-androst-1 en-3-one);

4-Androstenediol (androst-4-ene-3β, 17β-diol);

4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one);

5-Androstenedione (androst-5-ene-3,17-dione);

7a-hydroxy-DHEA;

7β-hydroxy-DHEA;

7-Keto-DHEA;

19-Norandrostenediol (estr-4-ene-3,17-diol);

19-Norandrostenedione (estr-4-ene-3,17-dione);

Androstanolone (5a-dihydrotestosterone, 17β-hydroxy-5a-androstan-3-one);

Androstenediol (androst-5-ene-3β,17β-diol);

Androstenedione (androst-4-ene-3,17-dione):

Bolasterone;

Boldenone;

Boldione (androsta-1,4-diene-3,17-dione);

Calusterone;

Clostebol;

Danazol ([1,2]oxazolo[4’,5’:2,3]pregna-4-en-20-yn-17a -ol);

Dehydrochlormethyltestosterone (4-chloro-17 β -hydroxy-17a-methylandrosta-1,4-dien-3-one);

Desoxymethyltestosterone (17a-methyl-5a -androst-2-en-17 β-ol and 17 a-methyl-5 a-androst-3-en-17β-ol);

Drostanolone;

Epiandrosterone (3β-hydroxy-5a-androst-17-one);

Epi-dihydrosterone (17β-hydroxy-5β-androstan-3-one);

Epitestosterone;

Ethylestrenol (19-norpregna-4-en-17a-ol);

Fluoxymesterone;

Formebolone;

Furazabol (17a -methyl [1,2,5]oxadiazolo(3’,4’:2,3)-5a-androstan-17β-ol);

Gestrinone;

Mestanolone;

Mesterolone;

Metandienone (17 β-hydroxy-17a -methylandrosta-1,4-dien-3-one);

Metenolone;

Methandriol;

Methasterone (17 β-hydroxy-2a,17a-dimethyl-5a-androstan-3-one);

Methyl-1-testosterone (17β-hydroxy-17a-methyl-5a -androst-1-en-3-one);

Methylclostebol;

Methyldienolone (17 β-hydroxy-17a-methylestra-4,9-dien-3-one);

Methylnortestosterone (17 β-hydroxy-17a-methyl-5a -4-en-3-one);

Methyltestosterone;

Metribolone (methyltrienolone, 17β-hydroxy-17a-methylestra-4,9,11-trien-3-one);

Mibolerone;

Nandrolone (19-notestosterone);

Norboletone;

Norclostebol (4-chloro-17β-ol-estr-4-en-3-one);

Norethandrolone;

Oxabolone;

Oxandrolone;

0xymesterone;

Oxymetholone;

Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one);

Prostanozol (17β-((tetrahydropyran-2-yl)oxy)-1’H-pyrazolo(3,4:2,3)-5a-androstane);

Quinbolone;

Stanozolol;

Stenbolone;

Testosterone;

Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor-17a-pregna-4,9,11-trien-3-one);

Trenbolone (17 β-hydroxyestr-4,9,11-trien-3-one);

and other substances with a similar chemical structure or similar biological effect(s).

Other Anabolic Agents
Including, but not limited to:

Clenbuterol;
Selective androgen receptor modulators (SARMs, e.g. andarine, LGD-4033 (ligandrol), enobosarm (ostarine) and RAD 140), tibolone, zeranol and zilpaterol.

For purposes of this section:

“exogenous” refers to a substance which is not ordinarily produced by the body naturally.
** “endogenous” refers to a substance which is ordinarily produced by the body naturally.

S2. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS

The following substances, and other substances with similar chemical structure or similar biological effects(s), are prohibited:

Erythropoietins (EPO) and agents affecting erythropoiesis, including, but not limited to:
1.1 Erythropoietin-Receptor Agonists, e.g.

Darbepoetins (dEPO);

Erythropoietins (EPO);

EPO based constructs (e.g. EPO-Fc, methoxy polyethylene glycol-epoetin beta (CERA));

EPO-mimetic agents and their constructs (e.g. CNTO 530 and peginesatide).

1.2 Hypoxia-inducible factor (HIF) activating agents, e.g.

Cobalt;

Daprodustat (GSK1278863);

Molidustat (BAY 85-3934);

Roxadustat (FG-4592);

Vadadustat (AKB-6548);

Xenon.

1.3 GATA inhibitors, e.g.

K-11706

1.4 TGF-beta (TGF-β) signaling inhibitors, e.g.

Luspatercept;

Sotatercept.

1.5 Innate repair receptor agonists, e.g.

Asialo EPO;

Carbamylated EPO (CEPO).

Peptide Hormones and their Releasing Factors,
2.1 Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors in males, e.g. Buserelin, deslorelin, gonadorelin, goserelin, leuprorelin, nafarelin and triptorelin;

2.2 Corticotrophins and their releasing factors, e.g. Corticorelin;

2.3 Growth Hormone (GH), its fragments and releasing factors, including, but not limited to: Growth Hormone fragments, e.g. ADD-9604 and hGH 176-191;

Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1293, CJC-1295, sermorelin and tesamorelin; Growth Hormone Secretagogues

(GHS), e.g. Lenomorelin (ghrelin) and its mimetics, e.g. Anamorelin, ipamorelin, macimorelin and tabimorelin; GH-Releasing Peptides (GHRPs), e.g. Alexamorelin, GHRP-1,

GHRP-2 (pralmorelin), GHRP-3, GHRP-4, GHRP-5, GHRP-6, and examorelin (hexarelin).

Growth Factors and Growth Factor Modulators, including, but not limited to:
Fibroblast Growth Factors (FGFs);

Hepatocyte Growth Factor (HGF);

Insulin-like Growth Factor-1 (IGF-1) and its analogues;

Mechano Growth Factors (MGFs);

Platelet-Derived Growth Factor (PDGF);

Thymosin- β4 and its derivatives e.g. TB-500;

Vascular-Endothelial Growth Factor (VEGF);

and other growth factors or growth factor modulators affecting muscle, tendon or ligament protein synthesis/degradation, vascularization, energy utilization, regenerative capacity or fibre type switching.

S3. BETA-2 AGONISTS

All selective and non-selective beta-2 agonists, including all optical isomers, are prohibited.

Including, but not limited to:

Fenoterol;

Formoterol;

Higenamine;

Indacaterol;

Olodaterol;

Procaterol;

Reproterol;

Salbutamol;

Salmeterol;

Terbutaline;

Tretoquinol (trimetoquinol)

Tulobuterol;

Vilanterol.

Except:

Inhaled salbutamol: maximum 1600 micrograms over 24 hours in divided doses not to exceed 800 micrograms over 12 hours starting from any dose;
Inhaled formoterol: maximum delivered dose of 54 micrograms over 24 hours;
Inhaled salmeterol: maximum 200 micrograms over 24 hours.

The presence in urine of salbutamol in excess of 1000 ng/ml or formoterol in excess of 40 ng/ml is not consistent with therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of a therapeutic dose (by inhalation) up to the maximum dose indicated above.

S4. HORMONE AND METABOLIC MODULATORS

The following hormone and metabolic modulators are prohibited:

Aromatase inhibitors including, but not limited to:

2-Androstenol (5a-androst-2-en-17-ol);

2-Androstenone (5a-androst-2-en-17-one);

3-Androstenol (5a-androst-3-en-17-ol);

3-Androstenone (5a-androst-3-en-17-one);

4-Androstene-3,6,17 trione (6-oxo);

Aminoglutethimide;

Anastrozole;

Androsta-1,4,6-triene-3,17-dione (androstatrienedione);

Androsta-3,5-diene-7,17-dione (arimistane);

Exemestane;

Formestane;

Letrozole;

Testolactone.

Selective estrogen receptor modulators (SERMs) including, but not limited to:

Bazedoxifene;

Ospemifene;

Raloxifene;

Tamoxifen;

Toremifene.

Other anti-estrogenic substances including, but not limited to:

Clomifene;

Cylofenil;

Fulvestrant.

Agents preventing activin receptor IIB activation including, but not limited, to:

Activin A-neutralizing antibodies;

Activin receptor IIB competitors such as:

Decoy activin receptors (e.g. ACE-031);

Anti-activin receptor IIB antibodies (e.g. Bimagrumab);

Myostatin inhibitors such as:

Agents reducing or ablating myostatin expression;

Myostatin-binding proteins (e.g. Follistatin, myostatin, propeptide);

Myostatin-neutralizing antibodies (e.g. Domagrozumab, landogrozumab, stamulumab).

Metabolic modulators:
5.1 Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR, SR9009; and Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists, e.g. 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl) phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW 1516, GW501516);

5.2 Insulins and insulin-mimetics;

5.3 Meldonium;

5.4 Trimetazidine.

S5. DIURETICS AND OTHER MASKING AGENTS

The following diuretics and masking agents are prohibited, as are other substances with a similar chemical structure or similar biological effect(s).

Including, but not limited to:

Desmopressin; probenecid; plasma expanders, e.g. intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol;
Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. Bendroflumethiazide, chlorothiazide and hydrochlorothiazide; triamterene and vaptans, e.g. Tolvaptan.

Except:

Drospirenone; pamabrom; and ophthalmic use of carbonic anhydrase inhibitors (e.g. Dorzolamide, brinzolamide);
Local administration of felypressin in dental anaesthesia.

The detection in an Athlete’s Sample of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent, will be considered as an Adverse Analytical Finding (AAF) unless the Athlete has an approved Therapeutic Use Exemption (TUE) for that substance in addition to the one granted for the diuretic or masking agent.

S6. STIMULANTS

All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited.

Stimulants include:

a: Non-Specified Stimulants:

Adrafinil;

Amfepramone;

Amfetamine;

Amfetaminil;

Amiphenazole;

Benfluorex;

Benzylpiperazine;

Bromantan;

Clobenzorex;

Cocaine;

Cropropamide;

Crotetamide;

Fencamine;

Fenetylline;

Fenfluramine:

Fenproporex,

Fonturancetam (4-phenylpiracetam (carphedon));

Furfenorex;

Lisdexamfetamine;

Mefenorex;

Mephentermine;

Mesocarb;

Methamphetamine (d-);

p-methylamphetamine;

Modafinil;

Norfenfluramine;

Phendimetrazine;

Phentermine;

Prenylamine;

Prolintane.

A stimulant not expressly listed in this section is a Specified Substance.

Specified Stimulants.
Including, but not limited to:

3-Methylhexan-2-amine (1,2-dimethylpentylamine);

4-Methylhexan-2-amine (methylhexaneamine);

4-Methylpentan-2-amine (1,3 dimethylbutylamine);

5-Methylhexan-2-amine (1,4-dimethylpentylamine);

Benzfetamine;

Cathine**

Cathinone and its analogues, e.g. mephedrone, methedrone, and α-pyrrolidinovalerophenone;

Dimetamfetamine (dimethylamphetamine);

Ephedrine***;

Epinephrine**** (adrenaline);

Etamivan;

Etilamfetamine;

Etilefrine;

Famprofazone;

Fenbutrazate;

Fencamfamin;

Heptaminol;

Hydroxyamfetamine (parahydroxyaphetamine);

Isometheptene;

Levmetamfetamine;

Meclofenoxate;

Methylenedioxymethamphetamine;

Methyephedrine***;

Methylphenidate;

Nikethaminde;

Norfenefrine;

Octodrine (1,5-dimethylhexylamine);

Octopamine;

Oxilofrine (methylsynephrine);

Pemoline;

Penetrazol;

Phenethylamine and its derivatives;

Phenmetrazine;

Phenpromethamine;

Propylhexedrine;

Pseudoephedrine*****;

Selegiline;

Sibutramine;

Strychnine;

Tenamfetamine (methylenedioxyamphetamine);

Tuaminoheptane;

and other substances with a similar chemical structure or similar biological effect(s).

Except:

Clonidine;
Imidazole derivatives for dermatological, nasal or ophthalmic use and those stimulants included in WADA’s 2020 Monitoring Program*.


 

*Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in WADA’s 2020 Monitoring Program,, and are not considered Prohibited Substances.

**Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter.

***Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater 10 micrograms per milliliter.

****Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents.