Australia’s Jackson (16-0-KO7) will enter the cauldron of Windsor Park as the underdog, with Frampton eyeing a shot at a world ruler by the end of the year.
Frampton is aiming to become a three-time world champion having already secured two-weight status with memorable victories over the likes of Leo Santa Cruz and Scott Quigg.
Jackson captained Australia at the 2012 London Olympics and knew time was running out to secure a big fight at the age of 33.
Another local hero – triple Olympian Paddy Barnes – also stars on the card as he challenges Cristofer Rosales for the WBC world flyweight title.
Barnes is 5-0 since entering the paid ranks on the back of a stellar amateur career and now meets Rosales in the Nicaraguan’s first defense of the green belt.
Rosales shocked pound for pound star Daigo Higa in April before the now former champion was banned for failing the weight, with the 23 year-old scoring an unlikely ninth round knockout.
Lineal heavyweight king Tyson Fury completes a glitzy cast. An opponent is to be announced in the near future.
Fury, 29, returned from a long hiatus to beat Sefer Seferi in farcical circumstances and will step up in class on the massive stadium bill in the summer.
Hoping for an eventual shot at Anthony Joshua, Fury needs to stay active to blow off the cobwebs of a 31-month absence.