Smith (22-0, 17 KOs) is the No. 1 super middleweight contender, while Dirrell (30-1-1, 24 KOs) is second.
Dirrell comes from defeating Norbert Nemesapati of Hungary (25-5, 18 KOs), who was stopped in six.
Smith, a Liverpudlian, knocked out compatriot Luke Blackledge (22-3-2, 7 KOs) in the tenth round in Manchester, England.
“It’s a good fight, he’s a former champion and I’m undefeated. I feel 100% ready for this fight and I’ll continue training to conquer the green and gold belt,” said Smith.