An entertaining card at the Ariake Colosseum in Tokyo saw a shock result unfold on top billing in Japan.
In the main event, IBF light flyweight champion Akira Yaegashi lost his title in a devastating first round defeat to dangerous Filipino Milan Melindo.
The challenger was able to capitalize early on with some power punches against the three-weight world title holder before finishing the bout towards the end of the round.
With the victory, Melindo claims a version of the world title at the third attempt and in the process pushed his record to 36-2. Yaegashi dropped to 25-6 in suffering a first loss in six contests.
The co-feature involved fast-rising world star Naoya Inoue fighting in an eighth world title bout from just 13 outings.
His latest victim was Ricardo Rodriguez, who was taken out in three rounds as Inoue made a fifth successful defense of his WBO super-flyweight strap.
Super Featherweight contender Satoshi Hosono halted Masashi Noguchi in the first round, whilst Andy Hiraoka and Satoshi Shimizu both remained undefeated with stoppage wins of their own.
At the featherweight limit, Ryo Matsumoto pushed to 20-1 by taking out Hendrik Barongsay in two rounds, whilst Toru Kiyota scored a four-round points win in the same division.
At bantamweight, Hisaya Kishibe recorded his maiden career win against fellow struggler Akira Nakajima. Kishibe is now 1-2 as a pro.