So far, the two Britons have been involved in several scuffles in the build-up to their British title and WBC eliminator in Manchester this weekend and Hearn has now taken heed of a previous request by the UK Boxing Board.
Following a clash at the Sky Sports studios last month, the BBBofC asked Hearn to keep Whyte and Chisora apart, although the Matchroom boss was adamant the pair could be controlled until trouble erupted again when a table was thrown across the room.
Now, Hearn will not allow the two close enough to each other for a similar stunt to take place.
“(The final presser) wasn’t good and we will now ensure that the next time these fighters see each other will be in the ring on Saturday night,” Hearn told Sky Sports.
“They will weigh in at separate locations on Friday – let’s keep them apart and let them concentrate on a very important fight this weekend.”
Fight night pundit Johnny Nelson added: “When you train so hard for a fight, certain fighters wear their hearts on their sleeves. You’ve just got two guys who wear their hearts on their sleeves so this is going to happen.
“The best move is to keep them apart until fight night. Once the fight is over, it’s over. Emotions are released. All the hard training, all the focus you’ve had on that opponent, is done and dusted.”
Whyte v Chisora forms part of a massive night on Sky Sports Box Office.