The 29 year-old, already a two-weight world champion, fulfils a dream of headlining the bright lights of Las Vegas following victories in Texas and New York respectively since turning his attention Stateside.
Frampton cleaned up domestically when defeating Scott Quigg before embarking on the biggest test of his career opposite Santa Cruz, coming out on top in an entertaining twelve round battle in the summer.
The pair will do it all again at the world famous MGM Grand in another Showtime bonanza and Frampton believes he’s already got Santa Cruz’s number before a return punch is thrown in anger.
“The rematch is the fight we wanted,” said Frampton.
“”I enjoyed our first fight in New York. The atmosphere was fantastic and the fight lived up to the hype. On January 28th, I will be better and I will win more convincingly.
“I know the way Leo fights, he throws a lot of punches and he is brave, but his style suits me.
“It has always been a dream of mine to headline in Las Vegas and I cannot wait to get out there and put on a great performance for the American boxing fans and the travelling support from Ireland and the UK,” he added.