The 34 year-old, who was born in Italy before moving to the United States as a child, had been linked to fighting Gianluca Branco for the European title until accepting an offer to battle Danny Garcia in New York.
Upon being stopped by Garcia over summer, Malignaggi was unsure about continuing his career until an offer came from Italian-based promoter Alessandro Cherchi.
“Fighting in Italy has always been my dream and I am happy to carry on September 26 at the Teatro Principe. I was born to Italian parents in New York and I lived the first six years of my life in Italy, I feel Italian. I will certainly excited to fight in front of the Italian public,” Malignaggi told milanosportiva.com.
Cherchi added: “I am very proud to be able to bring a champion like Paul Malignaggi to Italy and I must thank OPI 2000 chaired by my father and my brother who in recent months have worked with the Americans to get this result.”
A victory for Malignaggi against an opponent to be named could then set up the New Yorker for a challenge against the winner of Branco versus mandatory welterweight challenger Leonard Bundu.