Liam Walsh punished inactive Joe Murray in a rematch of their September 2013 contest in which he scored a majority decision triumph.
This time around, the Cromer fighter was on top for the vast majority of the fight, breaking down the Manchester operator until he could go on no longer.
Murray, who by this time was sporting a badly bruised face, took a crunching uppercut in the fifth and walked away to the ropes until waved off.
With the victory, British and Commonwealth super featherweight champion Walsh moves on to 18-0 and one step nearer to a long-awaited world title shot.
Earlier, Bradley Skeete made swift work of Anzor Gamgebeli to claim the vacant WBO European welterweight title and put his first defeat firmly behind him.
The 27 year-old, who lost to Frankie Gavin via a unanimous decision back in November, stopped the Georgian in the very first round to improve to 19-1 with an eighth career KO.
Super bantamweight Lewis Pettitt did likewise as the Erith boxer halted David Kvaratskhelia to record a sixth stoppage from 16 wins with just a solitary loss.
Boy Jones Jnr scored a convincing victory on his professional debut to inflict a 24th career defeat on game journeyman Joe Beedon.
The Chingford boxer took every round from Beedon on his home patch to begin his stint in the paid ranks on the right foot 40-36.
Also on the bill, light heavyweight Dempsey Fury made it four wins out of four against Ernestas Dapkus to make a successful return from 20 months out of action, whilst Frank Buglioni scored a first round stoppage in a follow on bout.